The cytochromes P450 and mechanisms of chemical carcinogenesis.
نویسنده
چکیده
This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.
منابع مشابه
Human cytochromes P450: evolution and cDNA-directed expression.
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ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 102 شماره
صفحات -
تاریخ انتشار 1994